Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
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چکیده
منابع مشابه
Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
A recent study by Dr. Maria Antonietta De Luca demonstrated intravenous (IV) self-administration responding (nose-poking) for the synthetic cannabinoid JWH-018 [1-pentyl-3-(1-naphthoyl)indole] (Figure 1) in an experimentally naïve, adult rat species [1]. This finding is unexpected since the phytocannabinoid (−)-trans-Δ9tetrahydrocannabinol (Δ9-THC, Figure 1), a primary psychoactive constituent ...
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BACKGROUND Aroma, Spice, K2 and Dream are examples of a class of new and increasingly popular recreational drugs. Ostensibly branded "herbal incense", they have been intentionally adulterated with synthetic cannabinoids such as JWH-018 in order to confer on them cannabimimetic psychoactive properties while circumventing drug legislation. JWH-018 is a potent cannabinoid receptor agonist. Little ...
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A recent study by Dr. Maria Antonietta De Luca demonstrated intravenous (IV) selfadministration responding (nose-poking) of an endogenous compound in an experimentally naïve, adult rat species [1]. Surprisingly, response-dependent changes of visual stimulus were not presented in the study when the compound was injected. This finding is very unique since there is few if any endogenous compounds ...
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The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown to have abuse liability and were subsequently regulated by authorities. However, there are compounds that are still not regulated probably due to the lack of abuse liability studies. In the pres...
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K2, a synthetic cannabinoid (SC), is an emerging drug of abuse touted as "legal marijuana" and marketed to young teens and first-time drug users. Symptoms associated with K2 use include extreme agitation, syncope, tachycardia, and visual and auditory hallucinations. One major challenge to clinicians is the lack of clinical, pharmacological, and metabolic information for the detection and charac...
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ژورنال
عنوان ژورنال: Journal of Alcoholism & Drug Dependence
سال: 2015
ISSN: 2329-6488
DOI: 10.4172/2329-6488.1000e128